CJC-1295 without DAC is the name the catalogue uses for modified GRF (1-29): the first 29 residues of growth-hormone-releasing hormone with four substitutions and an amidated C-terminus. The modified GRF post explains what each substitution does and why the compound is paired with ipamorelin, and the DAC versus no-DAC post covers the two forms that share the name. This post does something narrower: it reads the certificate for the lot on sale, COA7601 for lot CJC10-0803, line by line, because "CJC-1295 COA" is a question people ask directly and deserve a direct answer.
The 10 mg vial carries this lot. The CJC-1295 + ipamorelin blend and the CJC-1295 + GHRP-6 blend carry their own certificates, which report this compound as one of two components.
What the five lines say
Issued by Bioviridian Inc. on 17 August 2026.
| Test | Method | Result | What it establishes |
|---|---|---|---|
| Identity | LC-MS/MS | 3367.9 observed | The modified, amidated 29-residue peptide; not sermorelin, not the DAC conjugate; fragment ladder consistent with the sequence |
| Purity | RP-HPLC, 214 nm | 99.76% | Main peak at 10.40 minutes is 99.76% of the UV-absorbing area |
| Content | Gravimetric against label | 10.38 mg | Four percent over the 10 mg label |
| Endotoxin | LAL | < 0.05 EU/mL | Below the reporting limit at the dilution tested |
| Heavy metals | ICP | < 0.01 ppm | Below the reporting limit |
What 3367.9 rules out
Three compounds share the CJC name or the GRF (1-29) sequence, and they differ in mass by amounts a mass spectrometer cannot miss.
| Compound | What it is | Average mass | Difference from this lot |
|---|---|---|---|
| Modified GRF (1-29), this lot | GRF (1-29) with four substitutions, amidated | 3367.9 | 0 |
| Sermorelin | GRF (1-29), unmodified, amidated | 3357.5 | 10.4 lighter |
| CJC-1295 with DAC | Modified GRF (1-29) with a maleimidoproprionic acid linker on a lysine | about 3647 | about 280 heavier |
Ten daltons separates this compound from sermorelin, which is the difference the four substitutions make in total: an aspartate-to-glutamine, an alanine, a leucine for a methionine, and a D-alanine for an alanine, which changes nothing in mass but everything in protease resistance. A certificate reporting 3357 would be sermorelin whatever the label said. A certificate reporting 3647 would be the DAC form. The sermorelin certificate on this site reports 3357.5, which is the clean comparison.
Tandem MS adds the fragment ladder, which is what confirms that the mass belongs to this sequence rather than to a coincidental one. The LC-MS post explains the tolerance and the sequence verification post the limits.
What the retention time of 10.40 minutes tells you
That a 29-residue peptide with two tyrosines, a phenylalanine, several leucines and isoleucines was well retained on the column. Deletion sequences, each lighter by one residue, elute close to but separately from the main peak when retention is this long, so the purity figure is discriminating in the way the area-percent post describes. On a dipeptide the same percentage would mean less.
How many micromoles is 10 mg?
The label's 10 mg at 3367.9 g/mol is 2.97 micromoles; the measured 10.38 mg is 3.08. That is the smallest molar amount in any 10 mg vial on the site, purely because the molecule is large. In a design that compares this compound with ipamorelin, which is 711.8 daltons, 10 mg of each is 3.0 micromoles against 14.0; the equimolar comparison post is built around exactly that arithmetic, and the molarity post has the method. At the listed price of $110 the vial is about $37 per micromole.
What stays reactive after the substitutions
Two of the four substitutions were made for stability: the asparagine at position 8 that deamidates in the native sequence became glutamine, and the methionine at position 27 that oxidises became leucine. That leaves a 29-residue peptide with no cysteine, no methionine and no tryptophan, which is unusually robust for its length.
What remains:
- Two tyrosines (positions 1 and 10). They absorb at 280 nm, so the peptide can be quantified by A280, as the A280 post describes; and tyrosine can oxidise slowly under light, so amber tubes are sensible.
- Aspartates at positions 3 and 25, each followed by a non-glycine residue: slow isomerisation at best. Keep stocks near neutral.
- Size and hydrophobicity. A 3.4 kDa peptide with a hydrophobic face sticks to plastic and can aggregate at high concentration. Low-binding tubes at the nanomolar end, and dissolve gently; the adsorption post and the aggregation post have the mechanisms.
- Storage. Lyophilized at minus 20 °C; solutions aliquoted and frozen. The reconstituted shelf-life post has the general rules.
- Diluent. Water or buffer; reconstitution solution only for a preserved multi-entry stock, per the diluent post.
Reading this certificate next to a blend's
The two blends that contain this compound each carry a certificate with two identity lines and two content lines. On the ipamorelin blend's current certificate the masses are 3367.9 and 711.8, and the content of each component is stated separately. That is what a real blend certificate looks like, and the blend certificate post explains why a single purity figure cannot cover two compounds. Reading the single-compound certificate first makes the blend's easier: the 3367.9 line should match this one.
Frequently asked questions
Does this certificate cover the DAC form?
No. The DAC form is about 280 daltons heavier and would report a different mass. This lot is modified GRF (1-29) without the linker.
How can a 10-dalton difference be trusted to separate this from sermorelin?
Mass spectrometers resolve far finer differences than ten daltons at this mass; the question is only whether the certificate reports the molecular ion, which it does. The LC-MS post covers tolerance.
Can it be quantified by A280?
Yes. Two tyrosines give it a usable extinction coefficient. The A280 post has the method.
Why is 10 mg so few micromoles?
Because the molecule is 3,368 daltons. A 10 mg vial of a 700-dalton peptide holds nearly five times as many molecules. Compare on moles.
What is CJC-1295 sold for?
Laboratory research. Every product on this site is for in-vitro research use only and not for human or animal use.
References
- PubChem, National Library of Medicine. Sermorelin, CID 16132413, C149H246N44O42S, 3357.9 g/mol. Read 2 October 2026. pubchem.ncbi.nlm.nih.gov/compound/16132413
- Jette L, Leger R, Thibaudeau K, et al. Human growth hormone-releasing factor (hGRF)1-29-albumin bioconjugates activate the GRF receptor on the anterior pituitary in rats: identification of CJC-1295 as a long-lasting GRF analog. Endocrinology 2005;146(7):3052-3058. doi.org/10.1210/en.2004-1286
- Bioviridian Inc. Certificate of analysis COA7601, lot CJC10-0803, issued 17 August 2026. Verification code on the certificate. bioviridians.com/coa-search.html
Every product mentioned is sold for laboratory research use only and is not for human or animal use. Nothing on this page describes or recommends use of the material sold here in humans or animals.
