PT-141 liquid spray

What is it for?

PT-141, the melanocortin receptor agonist also catalogued as bremelanotide, supplied in solution rather than as a lyophilised powder: 10 mg in 10 mL at 1.0 mg/mL, a nominal 100 micrograms per actuation. Supplying it ready-made removes the reconstitution step and the variability that comes with it, which is useful where a fixed concentration has to hold across a run. Refrigerate and protect from light.

Which guides use it?

• Concentration and syringe-unit table
• Bacteriostatic water and benzyl alcohol in cell work
• Storage guide

Related reading

• PT-141 and the melanocortin receptor familyFive receptors, one peptide family, and a selectivity problem that shaped decades of medicinal chemistry. What MC1R through MC5R are, where PT-141 sits among them, and why selectivity is the hard part.
• Cyclic peptides versus linear peptidesClosing a peptide into a ring removes the termini that enzymes attack and fixes a shape that would otherwise flicker between conformations. It also introduces a failure mode a linear chain cannot have.
• Why some peptides are supplied in solution rather than as a powderA lyophilised vial and a ready-made solution are two different trade-offs, not a better and a worse option. What you gain in fixed concentration you give up in shelf life, and which matters depends on the work.
• Which receptor does each research peptide act on? A target table for the catalogOne table giving the receptor or molecular target for every compound in the catalog, with the primary paper that established it. Five compounds act at named receptors; the rest work through actin binding, copper delivery, a mitochondrial pathway or as a cofactor. Which is which, and what it means for an assay.