PEP-TZP-2

What is PEP-TZP-2?

PEP-TZP-2 is a 39-amino-acid synthetic peptide with dual agonist activity at the GIP and GLP-1 receptors. It is the reference compound for research into dual incretin signalling: how activating both receptors together affects insulin secretion, gastric emptying, appetite pathways and body composition in preclinical models. Pepstral supplies PEP-TZP-2 as a lyophilized powder, 10 mg net peptide per vial, tested by an independent US laboratory before listing.

→Read the full PEP-TZP-2 research guide

→PEP-RTA-3 vs PEP-TZP-2: which fits the research question?

→PEP-SMG-1 vs PEP-TZP-2: which fits the research question?

What is PEP-TZP-2 studied for?

• Dual incretin receptor signalling and cAMP assays
• Beta-cell function and insulin secretion models
• Appetite and gastric-emptying pathways
• Comparisons against GLP-1-only agonists

All applications above are in-vitro or preclinical research contexts. PEP-TZP-2 is sold for laboratory research only and is not for human or animal use.

What does the certificate for lot TIR10-0803 show?

Every lot of PEP-TZP-2 is tested by an independent US laboratory before it is listed. The report for lot TIR10-0803 is in the COA library and the lot number printed on the vial matches it. The current results:

Test	Method	Lot TIR10-0803 result
Identity	LC-MS/MS	Conforms
Content	HPLC quantitation	10.18 mg
Purity	RP-HPLC (214 nm)	99.80%
Endotoxin	USP <85>	<0.05 EU/mL
Heavy metals	USP <232>	<0.01 ppm

How is PEP-TZP-2 handled and stored?

Sealed vials are stored at -20°C away from light and keep for 24 months. To reconstitute, add bacteriostatic water slowly down the inside wall of the vial and swirl until clear; never shake. Once in solution, keep at 2 to 8°C and use within our 28-day default for a preserved solution. The concentration table gives the dilution volumes and microlitre aliquots for this vial.

Frequently asked questions

Also ordered as part of metabolic trio and metabolic axis.

Related reading

• PEP-SMG-1: what the three structural modifications do, and why the salt form on a certificate mattersPEP-SMG-1 is a GLP-1 analogue with three deliberate modifications. What each one does, what the 4113.6 Da mass confirms, and why salt form is not a detail.
• PEP-TZP-2 is built on the GIP backbone, not GLP-1, and it is not a balanced dual agonistPEP-TZP-2 is a 39-residue GIP analogue that also activates the GLP-1 receptor. Why the backbone choice matters and what biased agonism means on the certificate.
• How to verify a certificate of analysis is genuine: eight checks, and one real discrepancy found in this libraryA certificate is a claim until you check it. Eight checks needing no equipment, applied to 114 certificates, including the one mismatch they found.
• Peptide stability in plasma and serum: how the in-vitro assay is run and what it can honestly predictHow the plasma stability assay is run: matrix choice, time course, controls, quenching, and the four things the result cannot tell you.