PEP-RTA-3

What is PEP-RTA-3?

PEP-RTA-3 is a synthetic 39-residue peptide that acts on three receptors at once: GIP, GLP-1 and the glucagon receptor. Researchers use it to study how combined incretin and glucagon signalling changes energy balance, glucose handling and adipose tissue in cell and animal models, and to compare triple-agonist activity against the single- and dual-agonist peptides that came before it. Pepstral supplies it as a lyophilized powder, 10 mg net peptide per vial, with the lot-matched certificate published before the vial is listed.

→Read the full PEP-RTA-3 research guide

→PEP-RTA-3 vs PEP-TZP-2: which fits the research question?

What is PEP-RTA-3 studied for?

• Incretin receptor pharmacology and receptor-selectivity assays
• Energy expenditure and adiposity models
• Glucose regulation and insulin-sensitivity studies
• Head-to-head comparisons with PEP-SMG-1 and PEP-TZP-2

All applications above are in-vitro or preclinical research contexts. PEP-RTA-3 is sold for laboratory research only and is not for human or animal use.

What does the certificate for lot RETA10-0803 show?

Every lot of PEP-RTA-3 is tested by an independent US laboratory before it is listed. The report for lot RETA10-0803 is in the COA library and the lot number printed on the vial matches it. The current results:

Test	Method	Lot RETA10-0803 result
Identity	LC-MS/MS	Conforms
Content	HPLC quantitation	10.61 mg
Purity	RP-HPLC (214 nm)	99.83%
Endotoxin	USP <85>	<0.05 EU/mL
Heavy metals	USP <232>	<0.01 ppm

How is PEP-RTA-3 handled and stored?

Sealed vials are stored at -20°C away from light and keep for 24 months. To reconstitute, add bacteriostatic water slowly down the inside wall of the vial and swirl until clear; never shake. Once in solution, keep at 2 to 8°C and use within our 28-day default for a preserved solution. The concentration table gives the dilution volumes and microlitre aliquots for this vial.

Frequently asked questions

Also ordered as part of metabolic trio.

Related reading

• How to read a PEP-RTA-3 certificate of analysis, field by fieldA PEP-RTA-3 COA field by field — identity, content, purity, endotoxin, heavy metals and retention time — read against a real published lot.
• What eleven PEP-RTA-3 certificates show about lot-to-lot consistencyPurity, content and retention time across eleven published PEP-RTA-3 lots. Every lot overfilled, purity between 99.70% and 99.9%, and retention time tracking the batch rather than the material.
• PEP-RTA-3 identity: the formula, the mass, and what LC-MS actually confirmsC221H342N46O68 and 4731.2 g/mol. What a mass spectrum confirms about PEP-RTA-3 identity, what the charge-state envelope means, and what identity testing cannot rule out.
• What "reta" means on a peptide label, and how to read the rest of the vialReta, reta/cagri, RETA10-0803. What the abbreviations on a PEP-RTA-3 label and lot code actually encode, and which parts are vendor shorthand rather than chemistry.