Most peptide handling advice is written for chains long enough to fold. At three residues there is no structure to lose, which removes some problems and introduces others.
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Co-formulating two peptides only works if neither destabilises the other. These two share a design feature that makes them unusually compatible — and the reasons are specific enough to be worth checking against any blend.
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A lyophilised vial and a ready-made solution are two different trade-offs, not a better and a worse option. What you gain in fixed concentration you give up in shelf life, and which matters depends on the work.
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Glutathione is defined by a thiol group that wants to give up an electron. Once in solution it pairs off into the disulphide GSSG, and the ratio between the two is the single most useful number about the material.
Read the post →One sulphur-sulphur bond closes the ring that makes oxytocin what it is. It is also the least stable thing in the molecule, and the reason the storage instruction reads the way it does.
Read the post →The blog covers buying, handling and research-design questions as they come up. The evergreen material lives in the guides: reading a certificate of analysis, storage and stability, one research guide per compound and the glossary.
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