What is PEP-TSM-G, and what is it studied for?

What is the structure of PEP-TSM-G?

The full 1-44 GHRH sequence, amidated, with the hexenoyl modification that extends half-life while preserving native receptor selectivity. Supplied lyophilized; identity by LC-MS against the calculated mass, purity by HPLC-UV.

Identifier	Value
Molecular formula	C221H366N72O67S
Molecular weight	5136 g/mol
Residues	44
CAS number	218949-48-5
PubChem CID	16137828
Current lot	TESA10-0803

How is PEP-TSM-G thought to work?

GHRH receptor activation on pituitary somatotrophs increases growth-hormone synthesis and pulsatile release, which raises hepatic IGF-1. Because it acts upstream of the pituitary rather than replacing growth hormone, the physiological feedback loops remain intact, which is the property that distinguishes GHRH analogues from exogenous GH in research design.

Which research areas use PEP-TSM-G?

Area	Typical models and endpoints
GHRH receptor pharmacology	Binding and activation compared with native GHRH and with CJC-1295.
GH and IGF-1 axis	Pulse profile and hepatic IGF-1 response in rodent and pituitary models.
Visceral adipose tissue	Lipolysis and adipose remodelling endpoints.
Comparative studies	Stabilised GHRH analogue against a GHRH plus secretagogue blend.

What does the published literature show?

Falutz and colleagues reported a trial of the corresponding prescription medicine in the New England Journal of Medicine in 2007, and that medicine was subsequently approved for its indication. Those are clinical results in a specific population and are cited only as the context for research interest; they do not describe research use of the material sold here.

How is PEP-TSM-G handled in the laboratory?

Dissolves readily. The sequence contains methionine, which oxidises; minimise headspace, protect from light, refrigerate at 2 to 8°C and use within the 28-day window. The concentration table covers dilution volumes and microlitre aliquots; the storage guide covers stability by compound class.

What does the current certificate show?

Lot TESA10-0803 tested at 99.79% purity by RP-HPLC (214 nm), identity confirmed by LC-MS/MS, endotoxin <0.05 EU/mL. The certificate is in the COA library and the lot number on the vial matches it. Sold as 10 mg per vial at $120, for laboratory research only.

Certificate history for PEP-TSM-G

Every certificate the library holds for this compound, newest first. A replaced lot stays listed so the history can be read; the certificate dataset reads all 114 together.

Frequently asked questions

References

1. Falutz J et al. Metabolic effects of a growth hormone-releasing factor in patients with HIV. N Engl J Med. 2007.
2. Stanley TL et al. Lancet HIV. 2019.

Clinical results cited above describe regulated trials of pharmaceutical products and are given as context for research interest only. Nothing on this page describes or recommends use of the material sold here in humans or animals.