What is epithalon, and what is it studied for?

What is the structure of Epithalon?

Four residues with free termini and no modifications, two acidic side chains and a C-terminal glycine, giving a net negative charge at neutral pH and immediate water solubility. It shares the Glu-Asp pair with pinealon but is a different, longer molecule with a different mass; the certificate's identity line distinguishes the two.

Identifier	Value
Molecular formula	C14H22N4O9
Molecular weight	390.35 g/mol
Residues	4
CAS number	64082-79-7
PubChem CID	219042
Current lot	EPIT10-0803

How is Epithalon thought to work?

The designers propose a direct interaction with DNA that alters gene expression, the same model proposed for the rest of the series and not independently established. The most cited specific finding is induction of telomerase activity and telomere elongation in cultured human somatic cells, reported by Khavinson and colleagues in 2003.

Which research areas use Epithalon?

Area	Typical models and endpoints
Telomerase expression	Human fibroblast cultures with telomerase activity and telomere-length readouts.
Pineal and circadian signalling	Rodent melatonin and pineal-function studies from the bioregulator programme.
Bioregulator comparisons	Side-by-side work with pinealon and the thymic short peptides.
Analytical chemistry	A tetrapeptide standard for early-eluting HPLC and MS method work.

What does the published literature show?

Khavinson, Bondarev and Butyugov reported telomerase induction in human somatic cells in the Bulletin of Experimental Biology and Medicine in 2003; Anisimov and Khavinson's 2010 Biogerontology review summarises the rodent work. The literature is from one laboratory group with sparse independent replication, and no clinical study is registered. The material here is for in-vitro and preclinical research only.

How is Epithalon handled in the laboratory?

Dissolves instantly in water or buffer. No oxidation-prone residues; aspartate can isomerise slowly at acidic pH, so hold stocks near neutral. Store lyophilized at minus 20 °C; aliquot solutions and freeze. The concentration table covers volumes and syringe units; the storage guide covers stability by compound class.

What does the current certificate show?

Lot EPIT10-0803 tested at 99.68% purity by RP-HPLC (214 nm), identity confirmed by LC-MS/MS, endotoxin <0.05 EU/mL. The certificate is in the COA library and the lot number on the vial matches it. Sold as 10 mg per vial at $60, for laboratory research only.

Certificate history for Epithalon

Every certificate the library holds for this compound, newest first. A replaced lot stays listed so the history can be read; the certificate dataset reads all 114 together.

Frequently asked questions

References

1. Khavinson VK, Bondarev IE, Butyugov AA. Epithalon peptide induces telomerase activity and telomere elongation in human somatic cells. Bull Exp Biol Med. 2003;135(6):590-592.
2. Anisimov VN, Khavinson VK. Peptide bioregulation of aging: results and prospects. Biogerontology. 2010;11(2):139-149.
3. PubChem CID 219042, Epitalon. National Library of Medicine. Read 2 October 2026.

Clinical results cited above describe regulated trials of pharmaceutical products and are given as context for research interest only. Nothing on this page describes or recommends use of the material sold here in humans or animals.