What is pinealon, and what is it studied for?

What is the structure of Pinealon?

Three residues, glutamic acid, aspartic acid and arginine, written EDR, with free termini and no modifications. At neutral pH the two side-chain carboxyls, the C-terminal carboxyl, the arginine guanidinium and the N-terminal amine make it a small, highly polar zwitterion with a net charge near minus one, which is why it dissolves instantly and elutes early on a reversed-phase column.

Identifier	Value
Molecular formula	C15H26N6O8
Molecular weight	418.40 g/mol
Residues	3
CAS number	175175-23-2
PubChem CID	10273502
Current lot	PINE20-0803

How is Pinealon thought to work?

The designers propose that these short peptides enter cells and interact with DNA directly, altering transcription; the proposal is argued in their papers and is not an established receptor pharmacology. No receptor for pinealon has been identified. In the cell studies that exist, the measured outputs are viability and markers of oxidative stress, read after exposure of cultured cells to the peptide.

Which research areas use Pinealon?

Area	Typical models and endpoints
Cell viability	Cultured cell lines exposed to the peptide, with viability and proliferation readouts.
Oxidative stress markers	Free-radical and antioxidant-enzyme measurements in cell models.
Bioregulator comparisons	Side-by-side work with epithalon and other Khavinson tripeptides and tetrapeptides.
Analytical chemistry	A tripeptide standard for early-eluting HPLC and MS method work.

What does the published literature show?

Khavinson and colleagues reported in Rejuvenation Research in 2011 that pinealon raised viability and lowered free-radical levels in cultured cells. Anisimov and Khavinson's 2010 Biogerontology review places it in the pineal series and summarises rodent work. Independent replication is sparse and there is no registered clinical study; the material here is for in-vitro and preclinical research only.

How is Pinealon handled in the laboratory?

Dissolves in water or buffer immediately. No cysteine, methionine or tryptophan, so the usual oxidation routes do not apply; aspartate can slowly isomerise at acidic pH, so hold stocks near neutral. Store the lyophilized vial at minus 20 °C; aliquot solutions and freeze. The concentration table covers volumes and syringe units; the storage guide covers stability by compound class.

What does the current certificate show?

Lot PINE20-0803 tested at 99.68% purity by RP-HPLC (214 nm), identity confirmed by LC-MS/MS, endotoxin <0.05 EU/mL. The certificate is in the COA library and the lot number on the vial matches it. Sold as 20 mg per vial at $60, for laboratory research only.

Certificate history for Pinealon

Every certificate the library holds for this compound, newest first. A replaced lot stays listed so the history can be read; the certificate dataset reads all 114 together.

Frequently asked questions

References

1. Khavinson V, Ribakova Y, Kulebiakin K, et al. Pinealon increases cell viability by suppression of free radical levels and activating proliferative processes. Rejuvenation Res. 2011;14(5):535-541.
2. Anisimov VN, Khavinson VK. Peptide bioregulation of aging: results and prospects. Biogerontology. 2010;11(2):139-149.
3. PubChem CID 10273502, Pinealon. National Library of Medicine. Read 2 October 2026.

Clinical results cited above describe regulated trials of pharmaceutical products and are given as context for research interest only. Nothing on this page describes or recommends use of the material sold here in humans or animals.