PEP-SMG-1 is a GLP-1 analogue with three deliberate modifications. What each one does, what the 4113.6 Da mass confirms, and why salt form is not a detail.
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Dihexa is a peptidomimetic derived from angiotensin IV. Two of its four components are not amino acids, and that is what keeps it from being degraded.
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Short peptide bioregulators are two to four residues. Their molecular weights can be calculated by hand, which makes the certificate independently checkable.
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Net charge and hydropathy predict which solvent a peptide needs. Every catalogue sequence scored, and what each score means at the bench.
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Six degradation routes, each tied to one residue. Across 13 catalogue sequences the dominant route is not the one textbooks lead with.
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Freeze-drying is three stages, not one. What each does, why a cake collapses, and what the look of the powder can and cannot tell you.
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The closure is half the container. What the stopper is made of, why vials are backfilled, what coring is, and why entries are the limit.
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Water left in a freeze-dried cake drives most degradation. None of this library's 114 certificates measures it. What that does and does not mean.
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How the plasma stability assay is run: matrix choice, time course, controls, quenching, and the four things the result cannot tell you.
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Sum the residue masses, add one water. That reproduces the published formula for 11 catalogue compounds exactly. The four it misses are the lesson.
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A certificate is a claim until you check it. Eight checks needing no equipment, applied to 114 certificates, including the one mismatch they found.
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When a peptide needs an organic cosolvent, what concentration cells tolerate, and why the vehicle control cannot be skipped.
Read the post →The blog covers buying, handling and research-design questions as they come up. The evergreen material lives in the guides: reading a certificate of analysis, storage and stability, one research guide per compound and the glossary.
New posts publish to the RSS feed. Every post is written for laboratory research use only and links to the lot certificate for any product it mentions.
One email when a new certificate is published, when a sold-out compound is back, or when a new compound is added. About twice a month, nothing else.