DSIP 5 mg

What is DSIP?

DSIP, delta sleep-inducing peptide, is a nine-residue peptide first isolated from rabbit cerebral venous blood during induced sleep. Its receptor has never been definitively identified, which is the single most important caveat to record when working with it. Pepstral supplies it as a lyophilized powder for in-vitro laboratory research only.

→Read the full DSIP research guide

What is DSIP studied for?

• Sleep architecture models
• Stress-response and corticotropin studies
• Chronobiology research
• Peptide stability and transport assays

All applications above are in-vitro or preclinical research contexts. DSIP is sold for laboratory research only and is not for human or animal use.

What does the certificate for lot DSIP5-0803 show?

Every lot of DSIP is tested by an independent US laboratory before it is listed. The report for lot DSIP5-0803 is in the COA library and the lot number printed on the vial matches it. The current results:

How is DSIP handled and stored?

Sealed vials are stored at -20°C away from light and keep for 24 months. To reconstitute, add bacteriostatic water slowly down the inside wall of the vial and swirl until clear; never shake. Once in solution, keep at 2 to 8°C and use within our 28-day default for a preserved solution. The concentration table gives the dilution volumes and microlitre aliquots for this vial.

Frequently asked questions

Related reading

• Quantifying a peptide by A280, and why it does not work for most of this catalogueA280 only sees tryptophan, tyrosine and cystine. Most of this catalogue has none of them, so the reading is zero. What to use instead.
• Peptide stability in plasma and serum: how the in-vitro assay is run and what it can honestly predictHow the plasma stability assay is run: matrix choice, time course, controls, quenching, and the four things the result cannot tell you.
• Which residues degrade first: a map of peptide breakdown chemistry, and what it says about this catalogueSix degradation routes, each tied to one residue. Across 13 catalogue sequences the dominant route is not the one textbooks lead with.
• DSIP: the nine-residue sequence, the 1977 rabbit experiments, the receptor nobody has found, and what a 5 mg certificate showsDSIP is the nonapeptide Trp-Ala-Gly-Gly-Asp-Ala-Ser-Gly-Glu, mass 848.8. The 1977 isolation, the missing receptor, and what the certificate shows.