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Nootropics & Neuro · SKU P22-10
PE-22-28 10 mg
Spadin analogue studied for TREK-1 channel blockade.
$70 per 10 mg vial · free shipping over $1,000
In stock · ships same day on orders before 2pm ET
10 mg · lot PE2228-052899.9% purity by RP-HPLC (214 nm) · content 10.21 mg · certificate
IdentityPE-22-28 confirmed by MALDI-MS
Endotoxin<0.05 EU/mL
Heavy metals<0.01 ppm
LaboratoryBioviridian Inc. · code COA4859 · check it on the lab's site
FormLyophilized powder, sealed vial
Storage-20°C sealed · 2-8°C reconstituted
CAS number1801959-12-5
Molecular formulaC35H55N11O9
Molecular weight773.9 g/mol
Residues7
PubChemCID 165437303
Buying in quantity?
Wholesale pricing starts at 25 vials per SKU, with net-30 terms for verified institutions. It is quoted per order rather than applied in the cart — ask for a wholesale quote.
Every lot of PE-22-28 in the COA library · Latest lot report
Ships same day on orders before 2pm ET. For laboratory research use only. Not for human or animal consumption.
Frequently bought together
Supplies researchers add to this order
Reconstitution solution30 mL · $25
What is PE-22-28?
PE-22-28 is a truncated analogue of spadin, itself a fragment of the sortilin propeptide, and is studied as a blocker of the TREK-1 potassium channel. TREK-1 blockade is of interest because the channel has been linked to mood regulation in knockout models. Pepstral supplies it as a lyophilized powder for in-vitro laboratory research only.
→Read the full PE-22-28 research guide
What is PE-22-28 studied for?
- TREK-1 channel blockade assays
- Spadin fragment comparisons
- Electrophysiology studies
- Mood-related signalling research
All applications above are in-vitro or preclinical research contexts. PE-22-28 is sold for laboratory research only and is not for human or animal use.
What does the certificate for lot PE2228-0528 show?
Every lot of PE-22-28 is tested by an independent US laboratory before it is listed. The report for lot PE2228-0528 is in the COA library and the lot number printed on the vial matches it. The current results:
| Test | Method | Lot PE2228-0528 result |
|---|---|---|
| Identity | MALDI-MS | PE-22-28 · conforms |
| Content | HPLC quantitation | 10.21 mg |
| Purity | RP-HPLC (214 nm) | 99.9% |
| Endotoxin | USP <85> | <0.05 EU/mL |
| Heavy metals | USP <232> | <0.01 ppm |
| Sterility | USP <71> | Not Detected |
How is PE-22-28 handled and stored?
Sealed vials are stored at -20°C away from light and keep for 24 months. To reconstitute, add bacteriostatic water slowly down the inside wall of the vial and swirl until clear; never shake. Once in solution, keep at 2 to 8°C and use within our 28-day default for a preserved solution. The concentration table gives the dilution volumes and microlitre aliquots for this vial.
Frequently asked questions
What is TREK-1?
A two-pore-domain potassium channel. Its deletion produces a depression-resistant phenotype in mouse models, which is what makes blockers of it interesting.
How does PE-22-28 relate to spadin?
It is a shorter fragment of the same propeptide sequence, retaining the channel-blocking region.
Is PE-22-28 for human use?
No. Every product on this site is sold for in-vitro laboratory research only and is not for human or animal consumption, diagnostic or therapeutic use.
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