from$65
Nootropics & Neuro · SKU P22-10
PE-22-28 10 mg
Spadin analogue studied for TREK-1 channel blockade.
$ 70 per 10 mg vial · free shipping over $300
In stock · ships same day on orders before 2pm ET
Purity (HPLC-UV)≥99.0% on lot PE2-2609-X
IdentityConfirmed by LC-MS
FormLyophilized powder, sealed vial
Endotoxin< 0.5 EU/mg (LAL)
Storage-20°C sealed · 2-8°C reconstituted
CertificateView COA for PE2-2609-X →
CAS number1801959-12-5
Molecular formulaC35H55N11O9
Molecular weight773.9 g/mol
Residues7
PubChemCID 165437303
Volume pricing, applied automatically in the cart
| Quantity | Per unit | You save |
|---|---|---|
| 3 to 4 units | $65.10 | 7% |
| 5 to 9 units | $62.30 | 11% |
| 10+ units | $58.80 | 16% |
Verify lot PE2-2609-X in the COA library · This month's lot report
Ships same day on orders before 2pm ET. For laboratory research use only. Not for human or animal consumption.
Frequently bought together
Supplies researchers add to this order
Reconstitution solution30 mL · $25
Reconstitution kitKit · $49.99
What is PE-22-28?
PE-22-28 is a truncated analogue of spadin, itself a fragment of the sortilin propeptide, and is studied as a blocker of the TREK-1 potassium channel. TREK-1 blockade is of interest because the channel has been linked to mood regulation in knockout models. Pepstral supplies it as a lyophilized powder for in-vitro laboratory research only.
What is PE-22-28 studied for?
- TREK-1 channel blockade assays
- Spadin fragment comparisons
- Electrophysiology studies
- Mood-related signalling research
All applications above are in-vitro or preclinical research contexts. PE-22-28 is sold for laboratory research only and is not for human or animal use.
What does the certificate for lot PE2-2609-X show?
Every lot of PE-22-28 is tested by an independent US laboratory before it is listed. The report for lot PE2-2609-X is in the COA library and the lot number printed on the vial matches it. The current results:
| Test | Method | Lot PE2-2609-X result |
|---|---|---|
| Identity | LC-MS | Matches the calculated mass for the sequence |
| Purity | HPLC-UV, 220 nm | 99.0% |
| Net peptide content | Amino acid analysis | Stated per vial on the certificate |
| Endotoxin | LAL, chromogenic | < 0.5 EU/mg |
| Sterility | USP <71> | Pass |
How is PE-22-28 handled and stored?
Sealed vials are stored at -20°C away from light and keep for 24 months. To reconstitute, add bacteriostatic water slowly down the inside wall of the vial and swirl until clear; never shake. Once in solution, keep at 2 to 8°C and use within the 28-day window on the certificate. The reconstitution guide covers volumes and syringe units and the concentration table gives the numbers for this vial.
Frequently asked questions
What is TREK-1?
A two-pore-domain potassium channel. Its deletion produces a depression-resistant phenotype in mouse models, which is what makes blockers of it interesting.
How does PE-22-28 relate to spadin?
It is a shorter fragment of the same propeptide sequence, retaining the channel-blocking region.
Is PE-22-28 for human use?
No. Every product on this site is sold for in-vitro laboratory research only and is not for human or animal consumption, diagnostic or therapeutic use.
