What is DSIP, and what is it studied for?

What is the structure of DSIP?

Nine residues with free termini and no modifications, an N-terminal tryptophan, two acidic residues and no basic ones, giving a net negative charge at neutral pH. The tryptophan is the only chromophore above 250 nm and the residue most sensitive to light and oxidation. Its exact mass of 848.8 is confirmed by the certificate's identity line.

Identifier	Value
Molecular formula	C35H48N10O15
Molecular weight	848.8 g/mol
Residues	9
CAS number	62568-57-4
PubChem CID	68816
Current lot	DSIP5-0803

How is DSIP thought to work?

No receptor has been identified. The original reports described delta-wave EEG changes in rabbits after infusion; later work examined effects on stress hormones, body temperature and opioid systems in rodents, with inconsistent findings. Graf and Kastin's 1984 review already noted the variability, and the literature since has not resolved it.

Which research areas use DSIP?

Area	Typical models and endpoints
Neurophysiology	EEG and sleep-architecture recordings in rodent and rabbit models.
Neuroendocrine signalling	Corticotropin and other hormone measurements after peptide exposure in animals.
Peptide stability	A tryptophan-containing, glycine-rich sequence used in light- and protease-stability work.
Analytical chemistry	A nonapeptide standard with a strong tryptophan absorbance for A280 quantitation.

What does the published literature show?

Schoenenberger and Monnier described the peptide and its isolation in PNAS in 1977. Graf and Kastin reviewed the first decade of work in Neuroscience and Biobehavioral Reviews in 1984, noting both the reported effects and the failures to replicate them. There is no established mechanism and no registered clinical programme; the material is for in-vitro and preclinical research only.

How is DSIP handled in the laboratory?

Dissolves in water; a slightly basic buffer helps because of the acidic residues. Protect from light, since tryptophan photo-oxidises, and minimise headspace. Store lyophilized at minus 20 °C; aliquot solutions and freeze; avoid repeated freeze-thaw. The concentration table covers volumes and syringe units; the storage guide covers stability by compound class.

What does the current certificate show?

Lot DSIP5-0803 tested at 99.72% purity by RP-HPLC (214 nm), identity confirmed by LC-MS/MS, endotoxin <0.05 EU/mL. The certificate is in the COA library and the lot number on the vial matches it. Sold as 5 mg per vial at $55, for laboratory research only.

Certificate history for DSIP

Every certificate the library holds for this compound, newest first. A replaced lot stays listed so the history can be read; the certificate dataset reads all 114 together.

Frequently asked questions

References

1. Schoenenberger GA, Monnier M. Characterization of a delta-electroencephalogram (-sleep)-inducing peptide. Proc Natl Acad Sci USA. 1977;74(3):1282-1286.
2. Graf MV, Kastin AJ. Delta-sleep-inducing peptide (DSIP): a review. Neurosci Biobehav Rev. 1984;8(1):83-93.
3. PubChem CID 68816, Delta sleep-inducing peptide. National Library of Medicine. Read 2 October 2026.

Clinical results cited above describe regulated trials of pharmaceutical products and are given as context for research interest only. Nothing on this page describes or recommends use of the material sold here in humans or animals.