What is selank, and what is it studied for?

What is the structure of Selank?

Seven residues with free termini, two basic residues (lysine and arginine) and three prolines, giving a net positive charge at neutral pH and a rigid, protease-resistant tail. No cysteine, methionine or tryptophan, so it has no strong chromophore above 250 nm and no fast oxidation route. Mass 751.9 by the certificate's identity line.

Identifier	Value
Molecular formula	C33H57N11O9
Molecular weight	751.9 g/mol
Residues	7
CAS number	129954-34-3
PubChem CID	11765600
Current lot	SEL10-0803

How is Selank thought to work?

The parent tetrapeptide tuftsin modulates phagocyte function. Selank's reported central effects are associated with changes in the expression of genes involved in GABAergic transmission in rodent brain, as described by Volkova and colleagues in 2016; a direct receptor target is not established.

Which research areas use Selank?

Area	Typical models and endpoints
GABAergic gene expression	Transcript profiling in rodent brain regions after peptide exposure.
Immune signalling	Cytokine and phagocyte readouts descended from the tuftsin literature.
Behavioural pharmacology	Rodent anxiety-model paradigms in the Russian literature.
Analogue comparisons	Selank against semax and tuftsin in parallel assays.

What does the published literature show?

Kozlovskaya et al. (2003) described selank among tuftsin-family short peptides in Neuroscience and Behavioral Physiology; Volkova et al. (Frontiers in Pharmacology, 2016) reported effects on GABA-related gene expression in rats. Clinical reports concern the registered Russian nasal product, not the material here. No FDA or EMA approval exists; research use is in-vitro and preclinical.

How is Selank handled in the laboratory?

Dissolves instantly in water. Stable in solution relative to most peptides in the catalogue because it lacks oxidation-prone residues; still aliquot and freeze. Low adsorption at micromolar concentrations; use low-binding tubes below that. Store lyophilized at minus 20 °C. The concentration table covers volumes and syringe units; the storage guide covers stability by compound class.

What does the current certificate show?

Lot SEL10-0803 tested at 99.83% purity by RP-HPLC (214 nm), identity confirmed by LC-MS/MS, endotoxin <0.05 EU/mL. The certificate is in the COA library and the lot number on the vial matches it. Sold as 10 mg per vial at $65, for laboratory research only.

Certificate history for Selank

Every certificate the library holds for this compound, newest first. A replaced lot stays listed so the history can be read; the certificate dataset reads all 114 together.

Frequently asked questions

References

1. Kozlovskaya MM, Kozlovskii II, Val'dman EA, Seredenin SB. Selank and short peptides of the tuftsin family in the regulation of adaptive behavior in stress. Neurosci Behav Physiol. 2003;33(9):853-860.
2. Volkova A, Shadrina M, Kolomin T, et al. Selank administration affects the expression of some genes involved in GABAergic neurotransmission. Front Pharmacol. 2016;7:31.
3. PubChem CID 11765600, Selank. National Library of Medicine. Read 2 October 2026.

Clinical results cited above describe regulated trials of pharmaceutical products and are given as context for research interest only. Nothing on this page describes or recommends use of the material sold here in humans or animals.