What is 5-Amino-1MQ, and why is a non-peptide in a peptide catalogue?

What is the structure of 5-Amino-1MQ?

A methylated quinoline ring bearing an amino group at position 5, carrying a permanent positive charge on the ring nitrogen. The certificate reports it as an orange lyophilized powder, the one coloured non-copper lot in the library, and confirms the cation mass of 159.2 by LC-MS/MS. The counter-ion contributes to the vial's mass but not to the identity line.

Identifier	Value
Molecular formula	C10H11N2+ (cation)
Molecular weight	159.21 g/mol
Residues	not recorded
CAS number	685079-15-6
PubChem CID	950107
Current lot	5AM1MQ50-0803

How is 5-Amino-1MQ thought to work?

Competitive inhibitor of nicotinamide N-methyltransferase, reported by Neelakantan and colleagues in 2017 with cellular activity in adipocytes; inhibiting the enzyme spares nicotinamide for NAD+ synthesis and lowers 1-methylnicotinamide. The enzyme target is defined and the compound is used as a tool for it.

Which research areas use 5-Amino-1MQ?

Area	Typical models and endpoints
NNMT enzymology	Inhibition assays with recombinant enzyme.
NAD+ metabolism	Nicotinamide and NAD+ measurements in cultured adipocytes and muscle cells.
Adipocyte models	Differentiation and lipid-accumulation readouts in 3T3-L1 cells.
Small-molecule versus peptide handling	A case study in solubility and stability differences from the rest of the catalogue.

What does the published literature show?

Neelakantan et al. (Journal of Medicinal Chemistry, 2017) described the inhibitor series and effects in mice; a 2018 Biochemical Pharmacology report from the same group examined muscle stem cells. There is no clinical programme; research use is in-vitro and preclinical.

How is 5-Amino-1MQ handled in the laboratory?

Water-soluble as the salt; stable in solution for far longer than a peptide, with no residues to oxidise or hydrolyse. Light-protect as a precaution for a conjugated aromatic. Store lyophilized at room temperature or refrigerated per the certificate; freezing is unnecessary. The concentration table covers volumes and syringe units; the storage guide covers stability by compound class.

What does the current certificate show?

Lot 5AM1MQ50-0803 tested at 99.87% purity by RP-HPLC (214 nm), identity confirmed by LC-MS/MS, endotoxin <0.05 EU/mL. The certificate is in the COA library and the lot number on the vial matches it. Sold as 50 mg per vial at $80, for laboratory research only.

Certificate history for 5-Amino-1MQ

Every certificate the library holds for this compound, newest first. A replaced lot stays listed so the history can be read; the certificate dataset reads all 114 together.

Frequently asked questions

References

1. Neelakantan H, Vance V, Wetzel MD, et al. Selective and membrane-permeable small molecule inhibitors of nicotinamide N-methyltransferase reverse high fat diet-induced obesity in mice. Biochem Pharmacol. 2018;147:141-152.
2. Neelakantan H, Wang HY, Vance V, Hommel JD, McHardy SF, Watowich SJ. Structure-activity relationship for small molecule inhibitors of nicotinamide N-methyltransferase. J Med Chem. 2017;60(12):5015-5028.
3. PubChem CID 950107, 5-Amino-1-methylquinolinium. National Library of Medicine. Read 2 October 2026.

Clinical results cited above describe regulated trials of pharmaceutical products and are given as context for research interest only. Nothing on this page describes or recommends use of the material sold here in humans or animals.