What is P-21, and what is it studied for?

What is the structure of P-21?

The core is the CNTF-derived sequence Asp-Gly-Gly-Leu, acetylated at the N-terminus and amidated at the C-terminus, with an adamantylated glycine appended; the adamantane cage is the modification the adamantane post describes. Because no public registry record has been confirmed, the formula and mass fields on the product page are blank rather than estimated, and the certificate's identity line is the reference for this material's mass.

Identifier	Value
Molecular formula	not recorded
Molecular weight	not recorded
Residues	not recorded
CAS number	not recorded
PubChem CID	not recorded
Current lot	P21-5-0318

How is P-21 thought to work?

Designed to mimic the active region of ciliary neurotrophic factor; the reported mechanism in rodent work is an increase in brain-derived neurotrophic factor and downstream neurogenesis and synaptic markers. A receptor-level interaction has not been established; the compound is a peptidergic mimetic rather than a receptor ligand with a defined binding site.

Which research areas use P-21?

Area	Typical models and endpoints
Neurotrophic signalling	BDNF and synaptic-marker readouts in rodent brain.
Neurodegeneration models	Transgenic mouse models in the Iqbal laboratory's work.
Peptide design	Adamantylation as a stability strategy; comparison with the parent CNTF fragment.
Analytical chemistry	A modified tetrapeptide whose identity depends on the certificate's measured mass.

What does the published literature show?

Kazim and colleagues reported chronic oral treatment with the compound in a triple-transgenic mouse model in Neurobiology of Disease in 2014, and Kazim and Iqbal reviewed neurotrophic mimetics in Molecular Neurodegeneration in 2016. The work is from one laboratory group, in mice. There is no clinical programme; research use is in-vitro and preclinical.

How is P-21 handled in the laboratory?

Dissolves in water with swirling; the adamantyl group adds hydrophobicity, so a small fraction of organic co-solvent may be needed at high concentration. Store lyophilized at minus 20 °C; aliquot and freeze solutions; use low-binding tubes. The concentration table covers volumes and syringe units; the storage guide covers stability by compound class.

What does the current certificate show?

Lot P21-5-0318 tested at 99.8% purity by RP-HPLC (214 nm), identity confirmed by MALDI-MS, endotoxin <0.05 EU/mL. The certificate is in the COA library and the lot number on the vial matches it. Sold as 5 mg per vial at $120, for laboratory research only.

Certificate history for P-21

Every certificate the library holds for this compound, newest first. A replaced lot stays listed so the history can be read; the certificate dataset reads all 114 together.

Frequently asked questions

References

1. Kazim SF, Blanchard J, Dai CL, et al. Disease modifying effect of chronic oral treatment with a neurotrophic peptidergic compound in a triple transgenic mouse model of Alzheimer's disease. Neurobiol Dis. 2014;71:110-130.
2. Kazim SF, Iqbal K. Neurotrophic factor small-molecule mimetics mediated neuroregeneration and synaptic repair: emerging therapeutic modality for Alzheimer's disease. Mol Neurodegener. 2016;11:50.

Clinical results cited above describe regulated trials of pharmaceutical products and are given as context for research interest only. Nothing on this page describes or recommends use of the material sold here in humans or animals.