What is kisspeptin-10, and what is it studied for?
Kisspeptin-10 is the ten-residue C-terminal fragment of kisspeptin, the KISS1 gene product, formula C63H83N17O14, mass 1302.4, C-amidated. It is the shortest fragment with full activity at the receptor KISS1R, also called GPR54, and is studied in receptor pharmacology and in cell and animal models of the reproductive endocrine axis upstream of GnRH. The material here is for in-vitro research only.
What is the structure of Kisspeptin-10?
Ten residues ending in the RF-amide motif Arg-Phe-NH2 shared with related neuropeptides; the C-terminal amide is required for receptor activity. Two basic residues give a net positive charge at neutral pH. Mass 1302.4 is confirmed by the certificate's MALDI-MS identity line.
| Identifier | Value |
|---|---|
| Molecular formula | C63H83N17O14 |
| Molecular weight | 1302.4 g/mol |
| Residues | 10 |
| CAS number | 374675-21-5 |
| PubChem CID | 25240297 |
| Current lot | KISS10-0528 |
How is Kisspeptin-10 thought to work?
Agonist at KISS1R, a G-protein-coupled receptor coupled to Gq, raising intracellular calcium in cells expressing it. Kotani and colleagues identified kisspeptins as the natural ligands of the orphan receptor GPR54 in 2001, and Seminara and colleagues showed in 2003 that the receptor gene regulates puberty onset in humans and mice.
Which research areas use Kisspeptin-10?
| Area | Typical models and endpoints |
|---|---|
| KISS1R pharmacology | Calcium-flux and binding assays in cells expressing GPR54. |
| GnRH neuron signalling | Hypothalamic slice and cell models upstream of gonadotropin release. |
| Reproductive endocrinology | Rodent models of the hypothalamic-pituitary-gonadal axis. |
| RF-amide peptide comparisons | Structure-activity work across the kisspeptin fragments. |
What does the published literature show?
Kotani et al. (Journal of Biological Chemistry, 2001) identified the ligand-receptor pair; Seminara et al. (New England Journal of Medicine, 2003) reported the receptor's role in puberty. Clinical research with kisspeptin fragments exists in regulated academic settings and is context only. Research use of the material here is in-vitro and preclinical.
How is Kisspeptin-10 handled in the laboratory?
Dissolves in water; mildly acidic solutions help because of the basic residues. No methionine; a tryptophan makes it light-sensitive, so protect solutions. Store lyophilized at minus 20 °C; aliquot and freeze; low-binding tubes at nanomolar concentration. The concentration table covers volumes and syringe units; the storage guide covers stability by compound class.
What does the current certificate show?
Lot KISS10-0528 tested at 99.9% purity by RP-HPLC (214 nm), identity confirmed by MALDI-MS, endotoxin <0.05 EU/mL. The certificate is in the COA library and the lot number on the vial matches it. Sold as 10 mg per vial at $60, for laboratory research only.
Certificate history for Kisspeptin-10
Every certificate the library holds for this compound, newest first. A replaced lot stays listed so the history can be read; the certificate dataset reads all 114 together.
| Lot | Issued | Size | Identity | Purity | Content | Status |
|---|---|---|---|---|---|---|
| KISS10-0528 | Jun 17, 2026 | 10 mg | MALDI-MS | 99.9% | 10.05 mg | Current |
Frequently asked questions
Why the C-terminal amide?
Because the RF-amide motif is what the receptor recognises; the free-acid form is far less active. The certificate mass reflects the amidated form.
What does the current certificate show?
Lot KISS10-0528: identity by MALDI-MS at 1302.4, purity 99.9% by RP-HPLC at 214 nm, content 10.05 mg, endotoxin below 0.05 EU/mL, sterility not detected. Issued 17 June 2026.
How does it relate to kisspeptin-54?
Kisspeptin-54 is the full processed peptide; the 10-residue fragment is its C-terminus and retains full receptor activity, which is why it is the usual research tool.
References
- Kotani M, Detheux M, Vandenbogaerde A, et al. The metastasis suppressor gene KiSS-1 encodes kisspeptins, the natural ligands of the orphan G protein-coupled receptor GPR54. J Biol Chem. 2001;276(37):34631-34636.
- Seminara SB, Messager S, Chatzidaki EE, et al. The GPR54 gene as a regulator of puberty. N Engl J Med. 2003;349(17):1614-1627.
- PubChem CID 25240297, Kisspeptin-10. National Library of Medicine. Read 2 October 2026.
Clinical results cited above describe regulated trials of pharmaceutical products and are given as context for research interest only. Nothing on this page describes or recommends use of the material sold here in humans or animals.
Kisspeptin-10 10 mg
$60 per vial
Lot KISS10-0528 · 99.9% RP-HPLC (214 nm) · certificate published
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