What is AOD-9604, and what is it studied for?

What is the structure of AOD-9604?

Sixteen residues including two cysteines that form the disulfide loop of the parent hormone's C-terminus, which subtracts two daltons from the linear mass and is the structural feature to check against the certificate. The added tyrosine was included for radio-iodination in the original work. No growth-hormone receptor binding is attributed to the fragment.

Identifier	Value
Molecular formula	C78H123N23O23S2
Molecular weight	1815.1 g/mol
Residues	16
CAS number	221231-10-3
PubChem CID	71300630
Current lot	AOD5-0803

How is AOD-9604 thought to work?

Reported to act on lipid metabolism in rodent models through beta-3 adrenergic receptor-related pathways, without the growth-hormone receptor activity of the parent hormone; Heffernan and colleagues examined this in obese and beta-3 receptor knock-out mice in 2001. A receptor target is not established.

Which research areas use AOD-9604?

Area	Typical models and endpoints
Adipocyte lipid metabolism	Lipolysis and lipogenesis assays in cultured adipocytes.
Rodent metabolic models	Diet-induced models in the original Monash work.
Growth-hormone fragment pharmacology	Comparison with full-length hormone to separate metabolic from growth-promoting domains.
Disulfide peptide chemistry	A looped fragment for reduction and oxidation method work.

What does the published literature show?

Ng et al. (Hormone Research, 2000) and Heffernan et al. (Endocrinology, 2001) described the fragment's effects in mice. Clinical development for a metabolic indication was discontinued without approval; those trials describe a pharmaceutical candidate and are context only. Research use of the material here is in-vitro and preclinical.

How is AOD-9604 handled in the laboratory?

Dissolves in water; avoid reducing agents in diluents because of the disulfide. Contains methionine: protect from light and air. Store lyophilized at minus 20 °C; aliquot and freeze. The concentration table covers volumes and syringe units; the storage guide covers stability by compound class.

What does the current certificate show?

Lot AOD5-0803 tested at 99.78% purity by RP-HPLC (214 nm), identity confirmed by LC-MS/MS, endotoxin <0.05 EU/mL. The certificate is in the COA library and the lot number on the vial matches it. Sold as 5 mg per vial at $60, for laboratory research only.

Certificate history for AOD-9604

Every certificate the library holds for this compound, newest first. A replaced lot stays listed so the history can be read; the certificate dataset reads all 114 together.

Frequently asked questions

References

1. Ng FM, Sun J, Sharma L, Libinaki R, Jiang WJ, Gianello R. Metabolic studies of a synthetic lipolytic domain (AOD9604) of human growth hormone. Horm Res. 2000;53(6):274-278.
2. Heffernan M, Summers RJ, Thorburn A, et al. The effects of human GH and its lipolytic fragment (AOD9604) on lipid metabolism following chronic treatment in obese mice and beta(3)-AR knock-out mice. Endocrinology. 2001;142(12):5182-5189.
3. PubChem CID 71300630, AOD 9604. National Library of Medicine. Read 2 October 2026.

Clinical results cited above describe regulated trials of pharmaceutical products and are given as context for research interest only. Nothing on this page describes or recommends use of the material sold here in humans or animals.